| 1. Round | 06/01/2013 | Club San Luis | - | Santos Laguna | 1:1 | ||||
| 2. Round | 12/01/2013 | Cruz Azul | - | Club San Luis | 2:1 | ||||
| 3. Round | 20/01/2013 | Club San Luis | - | Monarcas Morelia | 1:2 | ||||
| 4. Round | 27/01/2013 | CF Monterrey | - | Club San Luis | 3:2 |  |
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| 5. Round | 03/02/2013 | Deportivo Guadalajara | - | Club San Luis | 1:1 | ||||
| 6. Round | 10/02/2013 | Club San Luis | - | Puebla FC | 1:3 | ||||
| 7. Round | 17/02/2013 | Club León | - | Club San Luis | 2:0 | ||||
| 9. Round | 03/03/2013 | CF Pachuca | - | Club San Luis | 2:1 | ||||
| 11. Round | 16/03/2013 | CF América | - | Club San Luis | 1:1 | ||||
| 17. Round | 05/05/2013 | Deportivo Toluca | - | Club San Luis | 0:1 |
Mexico