| 3. Round | 05/10/2021 | Coras de Nayarit | - | Mazorqueros | 0:2 | ||||
| 4. Round | 09/10/2021 | Mazorqueros | - | Mineros de Fresnillo FC | 0:0 | ||||
| 7. Round | 23/10/2021 | Cimarrones de Sonora II | - | Mazorqueros | 1:2 | ||||
| 9. Round | 06/11/2021 | Tritones Vallarta | - | Mazorqueros | 1:5 |  |
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| 11. Round | 13/11/2021 | Gavilanes de Matamoros | - | Mazorqueros | 0:3 | |
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| 12. Round | 20/11/2021 | Correcaminos UAT II | - | Mazorqueros | 0:1 | ||||
| 13. Round | 27/11/2021 | Mazorqueros | - | Tecos Fútbol Club | 3:0 | |
Mexico