| 1. Round | 28/07/2020 | CF Pachuca | - | CF América | 1:2 |  |
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| 2. Round | 02/08/2020 | CF América | - | Club Tijuana | 4:0 | ||||
| 3. Round | 08/08/2020 | Club Necaxa | - | CF América | 1:1 | ||||
| 4. Round | 14/08/2020 | CF América | - | Santos Laguna | 3:1 | ||||
| 5. Round | 17/08/2020 | Gallos Blancos | - | CF América | 4:1 | |
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| 6. Round | 23/08/2020 | CF América | - | CF Monterrey | 1:3 | ||||
| 7. Round | 30/08/2020 | Atlético San Luis | - | CF América | 1:2 | ||||
| 8. Round | 03/09/2020 | CF América | - | Mazatlán FC | 3:1 | ||||
| 9. Round | 09/09/2020 | Puebla FC | - | CF América | 2:3 | ||||
| 10. Round | 13/09/2020 | CF América | - | Deportivo Toluca | 1:1 | ||||
| 11. Round | 20/09/2020 | CF América | - | Deportivo Guadalajara | 1:0 | ||||
| 12. Round | 28/09/2020 | Cruz Azul | - | CF América | 0:0 | ||||
| 13. Round | 04/10/2020 | CF América | - | Pumas UNAM | 2:2 | ||||
| 14. Round | 20/10/2020 | Club León | - | CF América | 3:2 | |
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| 15. Round | 25/10/2020 | CF América | - | Atlas Guadalajara | 1:0 | ||||
| 16. Round | 01/11/2020 | CF América | - | UANL Tigres | 3:1 | |
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| 17. Round | 07/11/2020 | FC Juárez | - | CF América | 1:1 |
Mexico