| 2. Round | 08/02/2025 | River Plate | - | Defensor Sporting | 0:1 | ||||
| 3. Round | 16/02/2025 | Defensor Sporting | - | Racing | 2:0 | ||||
| 4. Round | 23/02/2025 | Plaza Colonia | - | Defensor Sporting | 1:2 |  |
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| 5. Round | 07/03/2025 | Defensor Sporting | - | Liverpool | 0:1 | ||||
| 6. Round | 16/03/2025 | Juventud de Las Piedras | - | Defensor Sporting | 2:1 | ||||
| 7. Round | 23/03/2025 | Defensor Sporting | - | Cerro Largo | 0:0 | ||||
| 8. Round | 27/03/2025 | Danubio | - | Defensor Sporting | 1:1 | ||||
| 9. Round | 01/04/2025 | Defensor Sporting | - | Miramar Misiones | 2:0 | |
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| 10. Round | 07/04/2025 | Montevideo Wanderers | - | Defensor Sporting | 0:0 | ||||
| 14. Round | 03/05/2025 | Defensor Sporting | - | Peñarol | 0:1 |
Uruguay
Italy