| 2. Round | 28/07/2018 | TM Fútbol Club | - | Atlético San Luis | 1:2 |  |
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| 5. Round | 19/08/2018 | Club Celaya | - | Atlético San Luis | 0:4 | ||||
| 7. Round | 02/09/2018 | FC Juárez | - | Atlético San Luis | 1:0 | |
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| 9. Round | 22/09/2018 | Cimarrones de Sonora | - | Atlético San Luis | 1:1 | ||||
| 12. Round | 20/10/2018 | Atlético San Luis | - | Cafetaleros de Tapachula | 3:1 |
Mexico