| 1. Round | 12/08/2000 | Rosario Central | - | Almagro | 1:1 |  |
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| 3. Round | 20/08/2000 | Talleres de Córdoba | - | Almagro | 1:0 | ||||
| 4. Round | 26/08/2000 | Almagro | - | CA Los Andes | 2:2 | ||||
| 5. Round | 04/09/2000 | San Lorenzo | - | Almagro | 2:0 | ||||
| 6. Round | 10/09/2000 | Almagro | - | Chacarita Juniors | 0:1 | ||||
| 7. Round | 16/09/2000 | Boca Juniors | - | Almagro | 2:0 | |
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| 8. Round | 24/09/2000 | Almagro | - | Argentinos Juniors | 0:0 | ||||
| 9. Round | 30/09/2000 | Unión de Santa Fe | - | Almagro | 3:0 | ||||
| 10. Round | 15/10/2000 | Almagro | - | Gimnasia de La Plata | 0:1 | ||||
| 11. Round | 22/10/2000 | Newell's Old Boys | - | Almagro | 1:1 | ||||
| 12. Round | 28/10/2000 | Almagro | - | Racing Club | 0:2 | |
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| 13. Round | 04/11/2000 | Belgrano de Córdoba | - | Almagro | 1:0 | ||||
| 14. Round | 10/11/2000 | Estudiantes | - | Almagro | 3:2 | ||||
| 15. Round | 18/11/2000 | Almagro | - | Huracán | 1:1 | ||||
| 16. Round | 26/11/2000 | Lanús | - | Almagro | 1:1 | |
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| 17. Round | 02/12/2000 | Almagro | - | River Plate | 4:5 | ||||
| 18. Round | 07/12/2000 | Vélez Sarsfield | - | Almagro | 2:3 |  |
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