1. Round | 17/07/2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
2. Round | 21/07/2022 | Club Nacional | - | Resistencia SC | 1:1 | ||||
3. Round | 25/07/2022 | 12 de Octubre de Itauguá | - | Club Nacional | 1:2 | ||||
4. Round | 30/07/2022 | Club Nacional | - | Sol de América | 3:0 | ||||
6. Round | 14/08/2022 | Guaraní | - | Club Nacional | 1:1 | ||||
8. Round | 26/08/2022 | Guaireña FC | - | Club Nacional | 1:3 | ||||
9. Round | 03/09/2022 | Club Nacional | - | Tacuary | 1:0 | ||||
10. Round | 11/09/2022 | Sportivo Ameliano | - | Club Nacional | 1:2 | ||||
12. Round | 19/09/2022 | Club Nacional | - | General Caballero DJLM | 1:0 | ||||
13. Round | 25/09/2022 | Resistencia SC | - | Club Nacional | 0:1 | ||||
14. Round | 03/10/2022 | Club Nacional | - | 12 de Octubre de Itauguá | 1:0 | ||||
15. Round | 06/10/2022 | Sol de América | - | Club Nacional | 2:3 | ||||
22. Round | 12/11/2022 | Club Olimpia | - | Club Nacional | 1:1 |