| 2. Round | 16/02/2022 | Gimnasia de La Plata II | - | San Lorenzo II | 2:1 | ||||
| 5. Round | 04/03/2022 | San Lorenzo II | - | River Plate II | 0:4 | ||||
| 6. Round | 12/03/2022 | Talleres de Córdoba II | - | San Lorenzo II | 2:3 | ||||
| 7. Round | 21/03/2022 | San Lorenzo II | - | Huracán II | 0:0 | ||||
| 8. Round | 04/04/2022 | San Lorenzo II | - | Atlético Tucumán II | 1:1 | ||||
| 13. Round | 30/04/2022 | Newell's Old Boys II | - | San Lorenzo II | 0:3 |  |
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| 14. Round | 09/05/2022 | San Lorenzo II | - | Racing Club II | 3:1 |
Argentina