| 1. Round | 04/06/2022 | San Lorenzo | - | Independiente | 1:1 | ||||
| 2. Round | 10/06/2022 | Newell's Old Boys | - | San Lorenzo | 0:0 | ||||
| 3. Round | 14/06/2022 | San Lorenzo | - | Arsenal de Sarandí | 3:3 | ||||
| 4. Round | 22/06/2022 | Central Córdoba SdE | - | San Lorenzo | 0:2 | ||||
| 14. Round | 16/08/2022 | San Lorenzo | - | Platense | 2:0 | ||||
| 22. Round | 01/10/2022 | San Lorenzo | - | Huracán | 1:0 | ||||
| 23. Round | 04/10/2022 | Godoy Cruz | - | San Lorenzo | 0:0 | ||||
| 26. Round | 18/10/2022 | Sarmiento de Junín | - | San Lorenzo | 2:4 |
Argentina