| 5. Round | 12/03/2021 | Banfield II | - | San Lorenzo II | 2:1 | ||||
| 6. Round | 19/03/2021 | San Lorenzo II | - | Aldosivi II | 0:1 | ||||
| 7. Round | 29/03/2021 | Estudiantes II | - | San Lorenzo II | 4:1 | ||||
| 8. Round | 02/04/2021 | San Lorenzo II | - | Rosario Central II | 0:0 | ||||
| 11. Round | 23/04/2021 | River Plate II | - | San Lorenzo II | 2:1 | ||||
| 12. Round | 30/04/2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 |
Argentina