| 10. Round | 05/09/2021 | Platense II | - | San Lorenzo II | 1:1 | ||||
| 11. Round | 10/09/2021 | San Lorenzo II | - | Racing Club II | 0:0 | ||||
| 12. Round | 17/09/2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 13. Round | 24/09/2021 | San Lorenzo II | - | Defensa y Justicia II | 0:2 | ||||
| 14. Round | 01/10/2021 | Atlético Tucumán II | - | San Lorenzo II | 1:1 | ||||
| 15. Round | 11/10/2021 | San Lorenzo II | - | Colón de Santa Fe II | 1:1 | ||||
| 16. Round | 15/10/2021 | River Plate II | - | San Lorenzo II | 1:3 | ||||
| 17. Round | 18/10/2021 | San Lorenzo II | - | Lanús II | 0:0 | ||||
| 18. Round | 22/10/2021 | Huracán II | - | San Lorenzo II | 0:1 | ||||
| 19. Round | 31/10/2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 20. Round | 05/11/2021 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | ||||
| 3. Round | 11/11/2021 | Boca Juniors II | - | San Lorenzo II | 4:1 | ||||
| 21. Round | 18/11/2021 | San Lorenzo II | - | Gimnasia de La Plata II | 4:1 | ||||
| 22. Round | 23/11/2021 | Aldosivi II | - | San Lorenzo II | 1:0 | ||||
| 23. Round | 27/11/2021 | San Lorenzo II | - | Sarmiento de Junín II | 3:1 |
Argentina