| 1. Round | 29/07/2021 | TM Fútbol Club | - | Leones Negros | 3:2 | ||||
| 2. Round | 04/08/2021 | Mineros de Zacatecas | - | Leones Negros | 2:1 |  |
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| 3. Round | 13/08/2021 | Leones Negros | - | Dorados de Sinaloa | 0:0 | ||||
| 5. Round | 29/08/2021 | Leones Negros | - | Alebrijes de Oaxaca | 1:1 | ||||
| 16. Round | 14/11/2021 | Leones Negros | - | Cimarrones de Sonora | 3:2 | ||||
| 17. Round | 18/11/2021 | Tepatitlán | - | Leones Negros | 2:1 |
Mexico