| 8. Round | 09/04/2022 | Deportes Melipilla | - | Cobreloa | 0:0 |  |
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| 11. Round | 25/04/2022 | Deportes Temuco | - | Deportes Melipilla | 1:1 | ||||
| 13. Round | 08/05/2022 | Fernández Vial | - | Deportes Melipilla | 1:1 |  |
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| 14. Round | 12/05/2022 | Deportes Melipilla | - | CD Magallanes | 1:2 | ||||
| 15. Round | 16/05/2022 | Santiago Morning | - | Deportes Melipilla | 1:1 | |
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| 16. Round | 22/05/2022 | Deportes Melipilla | - | Santa Cruz | 1:0 | |
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| 17. Round | 29/05/2022 | Deportes Iquique | - | Deportes Melipilla | 3:0 | ||||
| 18. Round | 05/07/2022 | Universidad de Concepción | - | Deportes Melipilla | 1:1 | ||||
| 28. Round | 13/09/2022 | Deportes Melipilla | - | Deportes Temuco | 0:1 | ||||
| 31. Round | 09/10/2022 | CD Magallanes | - | Deportes Melipilla | 7:0 | |
Chile