| 5. Round | 27/07/2022 | Coyotes de Tlaxcala | - | CF Monterrey II | 1:1 | ||||
| 6. Round | 02/08/2022 | Alacranes de Durango | - | Coyotes de Tlaxcala | 3:0 |  |
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| 7. Round | 10/08/2022 | Atlético La Paz | - | Coyotes de Tlaxcala | 2:2 | |
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| 8. Round | 18/08/2022 | Coyotes de Tlaxcala | - | Club Celaya | 0:1 | ||||
| 9. Round | 24/08/2022 | Correcaminos UAT | - | Coyotes de Tlaxcala | 0:2 | ||||
| 11. Round | 08/09/2022 | Tapatío | - | Coyotes de Tlaxcala | 1:1 | |
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| 12. Round | 13/09/2022 | Mineros de Zacatecas | - | Coyotes de Tlaxcala | 1:1 | |
Mexico