| 3. Round | 18/02/2022 | Resistencia SC | - | Club Nacional | 3:1 | ||||
| 4. Round | 26/02/2022 | Guaraní | - | Resistencia SC | 3:3 | ||||
| 7. Round | 19/03/2022 | Resistencia SC | - | Cerro Porteño | 0:3 |  |
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| 10. Round | 18/04/2022 | Resistencia SC | - | General Caballero DJLM | 2:1 | ||||
| 11. Round | 21/04/2022 | Libertad | - | Resistencia SC | 2:2 | ||||
| 12. Round | 25/04/2022 | Tacuary | - | Resistencia SC | 3:1 | ||||
| 15. Round | 12/05/2022 | Resistencia SC | - | Guaraní | 1:2 | ||||
| 18. Round | 15/06/2022 | Cerro Porteño | - | Resistencia SC | 1:0 | ||||
| 19. Round | 19/06/2022 | Club Olimpia | - | Resistencia SC | 6:1 | ||||
| 20. Round | 22/06/2022 | Resistencia SC | - | 12 de Octubre de Itauguá | 0:1 | ||||
| 21. Round | 25/06/2022 | General Caballero DJLM | - | Resistencia SC | 2:1 | ||||
| 22. Round | 03/07/2022 | Resistencia SC | - | Libertad | 0:4 |
Argentina