| Group H | 06/04/2022 | Unión de Santa Fe | - | Atlético Junior | 1:1 | ||||
| Group H | 12/04/2022 | Oriente Petrolero | - | Unión de Santa Fe | 1:3 |  |
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| Group H | 27/04/2022 | Fluminense RJ | - | Unión de Santa Fe | 0:0 | ||||
| Group H | 05/05/2022 | Unión de Santa Fe | - | Oriente Petrolero | 2:0 | ||||
| Group H | 19/05/2022 | Unión de Santa Fe | - | Fluminense RJ | 0:0 |  |
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| Group H | 27/05/2022 | Atlético Junior | - | Unión de Santa Fe | 0:4 | ||||
| Round of 16 | 28/06/2022 | Nacional | - | Unión de Santa Fe | 2:0 | ||||
| Round of 16 | 05/07/2022 | Unión de Santa Fe | - | Nacional | 1:2 |
Argentina