| 2. Round | 26/01/2019 | Club Nacional | - | Guaraní | 0:2 | ||||
| 1. Round | 13/02/2019 | Club Nacional | - | Club Olimpia | 2:4 | ||||
| 6. Round | 18/02/2019 | Club Nacional | - | Sol de América | 0:1 | ||||
| 7. Round | 22/02/2019 | Cerro Porteño | - | Club Nacional | 1:1 | ||||
| 9. Round | 03/03/2019 | Deportivo Capiatá | - | Club Nacional | 1:0 | ||||
| 10. Round | 11/03/2019 | Club Nacional | - | General Díaz | 1:0 | ||||
| 11. Round | 16/03/2019 | River Plate | - | Club Nacional | 1:1 | ||||
| 12. Round | 24/03/2019 | Club Olimpia | - | Club Nacional | 0:0 | ||||
| 8. Round | 27/03/2019 | Club Nacional | - | Libertad | 0:1 | ||||
| 13. Round | 31/03/2019 | Guaraní | - | Club Nacional | 2:2 | ||||
| 14. Round | 04/04/2019 | Club Nacional | - | San Lorenzo | 3:1 |  |
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| 15. Round | 09/04/2019 | Sportivo Luqueño | - | Club Nacional | 1:1 | ||||
| 16. Round | 15/04/2019 | Club Nacional | - | Deportivo Santaní | 0:0 | ||||
| 17. Round | 22/04/2019 | Sol de América | - | Club Nacional | 3:1 | ||||
| 18. Round | 29/04/2019 | Club Nacional | - | Cerro Porteño | 0:3 | ||||
| 19. Round | 03/05/2019 | Libertad | - | Club Nacional | 1:2 | ||||
| 21. Round | 14/05/2019 | General Díaz | - | Club Nacional | 1:1 |
Argentina