| 1. Round | 18/01/2020 | Club Nacional | - | Guaireña FC | 3:0 | ||||
| 2. Round | 24/01/2020 | General Díaz | - | Club Nacional | 0:2 | ||||
| 3. Round | 02/02/2020 | Club Nacional | - | Libertad | 1:2 | ||||
| 4. Round | 08/02/2020 | San Lorenzo | - | Club Nacional | 1:1 | ||||
| 5. Round | 16/02/2020 | Club Nacional | - | Guaraní | 1:2 | ||||
| 7. Round | 29/02/2020 | Club Nacional | - | Club Olimpia | 1:0 |  |
|||
| 8. Round | 06/03/2020 | Club Nacional | - | Cerro Porteño | 0:0 | ||||
| 9. Round | 21/07/2020 | River Plate | - | Club Nacional | 1:1 | ||||
| 10. Round | 26/07/2020 | Club Nacional | - | Sportivo Luqueño | 1:2 | ||||
| 11. Round | 01/08/2020 | Sol de América | - | Club Nacional | 1:1 | ||||
| 12. Round | 07/08/2020 | Guaireña FC | - | Club Nacional | 0:0 | ||||
| 13. Round | 11/08/2020 | Club Nacional | - | General Díaz | 3:0 | ||||
| 14. Round | 17/08/2020 | Libertad | - | Club Nacional | 2:0 | ||||
| 15. Round | 21/08/2020 | Club Nacional | - | San Lorenzo | 2:0 | ||||
| 16. Round | 25/08/2020 | Guaraní | - | Club Nacional | 1:0 | ||||
| 17. Round | 30/08/2020 | Club Nacional | - | 12 de Octubre de Itauguá | 0:0 | ||||
| 18. Round | 06/09/2020 | Club Olimpia | - | Club Nacional | 4:0 | ||||
| 22. Round | 02/10/2020 | Club Nacional | - | Sol de América | 2:2 |
Argentina