1. Round | 04/02/2022 | Sol de América | - | Club Nacional | 0:0 | ||||
2. Round | 13/02/2022 | Club Nacional | - | Cerro Porteño | 2:3 | ||||
3. Round | 18/02/2022 | Resistencia SC | - | Club Nacional | 3:1 | ||||
4. Round | 25/02/2022 | Club Nacional | - | 12 de Octubre de Itauguá | 2:2 | ||||
5. Round | 04/03/2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
7. Round | 21/03/2022 | Tacuary | - | Club Nacional | 2:1 | ||||
12. Round | 26/04/2022 | Club Nacional | - | Sol de América | 0:3 |