| 2. Round | 10/06/2021 | Rocha | - | Central Español | 3:2 |  |
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| 3. Round | 16/06/2021 | Central Español | - | CA Cerro | 3:2 | ||||
| 4. Round | 26/06/2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
| 7. Round | 15/07/2021 | Racing | - | Central Español | 1:0 | ||||
| 8. Round | 24/07/2021 | Central Español | - | Villa Teresa | 2:1 | ||||
| 15. Round | 05/10/2021 | Central Español | - | Defensor Sporting | 1:0 | ||||
| 16. Round | 11/10/2021 | Central Español | - | Albion | 3:4 | ||||
| 22. Round | 25/11/2021 | Central Español | - | Rampla Juniors | 3:0 |
Uruguay