| 1. Round | 17/02/2022 | Deportes Melipilla | - | Universidad de Concepción | 0:2 | ||||
| 2. Round | 23/02/2022 | Rangers | - | Deportes Melipilla | 1:0 | ||||
| 3. Round | 02/03/2022 | Deportes Melipilla | - | Puerto Montt | 1:1 | ||||
| 11. Round | 25/04/2022 | Deportes Temuco | - | Deportes Melipilla | 1:1 |  |
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| 12. Round | 29/04/2022 | Deportes Melipilla | - | Barnechea | 2:1 | ||||
| 13. Round | 08/05/2022 | Fernández Vial | - | Deportes Melipilla | 1:1 | ||||
| 14. Round | 12/05/2022 | Deportes Melipilla | - | CD Magallanes | 1:2 | ||||
| 23. Round | 10/08/2022 | Deportes Melipilla | - | Unión San Felipe | 1:0 | ||||
| 25. Round | 25/08/2022 | Cobreloa | - | Deportes Melipilla | 1:0 | ||||
| 32. Round | 17/10/2022 | Deportes Melipilla | - | Santiago Morning | 2:1 | ||||
| 33. Round | 24/10/2022 | Santa Cruz | - | Deportes Melipilla | 2:1 | ||||
| 34. Round | 01/11/2022 | Deportes Melipilla | - | Deportes Iquique | 0:0 |
Chile