| 1. Round | 21/08/2000 | SBV Eindhoven | - | SC Cambuur | 0:2 | ||||
| 2. Round | 26/08/2000 | SC Cambuur | - | FC Zwolle | 1:1 |  |
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| 3. Round | 04/09/2000 | BV Veendam | - | SC Cambuur | 4:1 | ||||
| 4. Round | 09/09/2000 | SC Cambuur | - | MVV | 0:0 | ||||
| 5. Round | 17/09/2000 | Telstar | - | SC Cambuur | 3:3 | ||||
| 6. Round | 25/09/2000 | SC Cambuur | - | FC Den Bosch | 0:1 | ||||
| 7. Round | 30/09/2000 | ADO Den Haag | - | SC Cambuur | 1:1 | ||||
| 11. Round | 04/11/2000 | Go Ahead Eagles | - | SC Cambuur | 3:1 | ||||
| 12. Round | 11/11/2000 | SC Cambuur | - | BV Emmen | 3:3 | ||||
| 13. Round | 18/11/2000 | SC Cambuur | - | TOP Oss | 3:1 | |
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| 14. Round | 25/11/2000 | HFC Haarlem | - | SC Cambuur | 1:1 | ||||
| 15. Round | 02/12/2000 | SC Cambuur | - | Dordrecht '90 | 1:0 | ||||
| 16. Round | 09/12/2000 | Heracles Almelo | - | SC Cambuur | 1:0 |
Netherlands