| Group J | 17/09/2015 | RSC Anderlecht | - | AS Monaco | 1:1 | ||||
| Group J | 01/10/2015 | Qarabağ FK | - | RSC Anderlecht | 1:0 | ||||
| Group J | 22/10/2015 | RSC Anderlecht | - | Tottenham Hotspur | 2:1 | ||||
| Group J | 05/11/2015 | Tottenham Hotspur | - | RSC Anderlecht | 2:1 | ||||
| Group J | 26/11/2015 | AS Monaco | - | RSC Anderlecht | 0:2 |  |
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| Round of 32 | 18/02/2016 | RSC Anderlecht | - | Olympiakos Piraeus | 1:0 | ||||
| Round of 32 | 25/02/2016 | Olympiakos Piraeus | - | RSC Anderlecht | 1:2 aet | |
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| Round of 16 | 10/03/2016 | Shakhtar Donetsk | - | RSC Anderlecht | 3:1 | |
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| Round of 16 | 17/03/2016 | RSC Anderlecht | - | Shakhtar Donetsk | 0:1 |
Ghana