| 1. Round | 09/07/2022 | Universidad Catolica | - | Mushuc Runa | 2:1 |  |
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| 2. Round | 17/07/2022 | Mushuc Runa | - | 9 de Octubre | 3:1 |  |
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| 3. Round | 24/07/2022 | Mushuc Runa | - | Técnico Universitario | 0:0 | |
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| 4. Round | 31/07/2022 | Cumbayá | - | Mushuc Runa | 1:1 | |
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| 5. Round | 08/08/2022 | Barcelona | - | Mushuc Runa | 4:1 | |
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| 6. Round | 13/08/2022 | Mushuc Runa | - | Orense SC | 1:1 | |
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| 9. Round | 04/09/2022 | Macará | - | Mushuc Runa | 3:0 | |
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| 11. Round | 20/09/2022 | Guayaquil City | - | Mushuc Runa | 4:1 | |
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| 7. Round | 25/09/2022 | Delfín SC | - | Mushuc Runa | 0:0 |  |
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| 15. Round | 22/10/2022 | Deportivo Cuenca | - | Mushuc Runa | 3:1 |
Ecuador