| 1. Round | 25/07/2010 | Universitario de Sucre | - | Club San José | 2:2 |  |
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| 2. Round | 01/08/2010 | Club San José | - | Blooming | 2:0 | |
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| 3. Round | 08/08/2010 | Jorge Wilstermann | - | Club San José | 1:3 | |
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| 4. Round | 15/08/2010 | Club San José | - | The Strongest | 3:2 | ||||
| 6. Round | 28/08/2010 | Club San José | - | Real Potosí | 2:3 | ||||
| 12. Round | 03/10/2010 | Club San José | - | Universitario de Sucre | 2:1 | |
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| 14. Round | 10/10/2010 | Club San José | - | Jorge Wilstermann | 2:0 | ||||
| 15. Round | 17/10/2010 | The Strongest | - | Club San José | 1:2 | ||||
| 16. Round | 24/10/2010 | Club San José | - | CD Guabirá | 5:1 | |
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| 18. Round | 31/10/2010 | Club San José | - | Oriente Petrolero | 0:3 | |
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| 17. Round | 04/11/2010 | Real Potosí | - | Club San José | 1:3 | ||||
| 19. Round | 07/11/2010 | Club Aurora | - | Club San José | 4:1 | ||||
| 22. Round | 28/11/2010 | Club San José | - | La Paz FC | 1:0 |
Bolivia