| Zona B | 06/03/2021 | Cobán Imperial | - | Sanarate | 2:0 | ||||
| Zona B | 31/03/2021 | Cobán Imperial | - | Achuapa | 3:2 | ||||
| Zona B | 10/04/2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | ||||
| Interzone | 14/04/2021 | Cobán Imperial | - | Iztapa | 2:2 | ||||
| Interzone | 21/04/2021 | Cobán Imperial | - | Xelaju MC | 0:0 | ||||
| Quarter-finals | 09/05/2021 | Santa Lucía | - | Cobán Imperial | 3:0 |  |
Guatemala