2. Round | 19/09/2021 | OFI Heraklion | - | AEK Athen | 3:3 | ||||
4. Round | 27/09/2021 | PAS Giannina | - | OFI Heraklion | 1:1 | ||||
5. Round | 03/10/2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
10. Round | 20/11/2021 | Volos NFC | - | OFI Heraklion | 0:2 | ||||
16. Round | 04/01/2022 | Asteras Tripolis | - | OFI Heraklion | 1:0 |