11. Round | 02/10/2021 | FC-Astoria Walldorf | - | 1899 Hoffenheim II | 2:5 | ||||
12. Round | 08/10/2021 | 1899 Hoffenheim II | - | 1. FSV Mainz 05 II | 0:1 | ||||
13. Round | 16/10/2021 | TSV Schott Mainz | - | 1899 Hoffenheim II | 1:1 | ||||
14. Round | 22/10/2021 | 1899 Hoffenheim II | - | FK Pirmasens | 0:2 | ||||
15. Round | 26/10/2021 | Bahlinger SC | - | 1899 Hoffenheim II | 1:0 | ||||
16. Round | 30/10/2021 | 1899 Hoffenheim II | - | TSG Balingen | 1:2 | ||||
17. Round | 06/11/2021 | VfR Aalen | - | 1899 Hoffenheim II | 5:2 | ||||
20. Round | 26/11/2021 | SG Sonnenhof Großaspach | - | 1899 Hoffenheim II | 0:0 | ||||
21. Round | 03/12/2021 | 1899 Hoffenheim II | - | VfB Stuttgart II | 2:0 | ||||
22. Round | 11/12/2021 | FSV Frankfurt | - | 1899 Hoffenheim II | 3:0 | ||||
24. Round | 13/02/2022 | SV 07 Elversberg | - | 1899 Hoffenheim II | 2:1 | ||||
25. Round | 20/02/2022 | 1899 Hoffenheim II | - | Kickers Offenbach | 2:2 | ||||
27. Round | 06/03/2022 | 1899 Hoffenheim II | - | Rot-Weiß Koblenz | 1:1 | ||||
38. Round | 14/05/2022 | 1899 Hoffenheim II | - | TSV Steinbach Haiger | 0:2 |