| 1. Round | 16/02/2022 | Cobreloa | - | San Luis | 2:1 | ||||
| 2. Round | 22/02/2022 | San Luis | - | CD Magallanes | 0:2 | ||||
| 3. Round | 03/03/2022 | Barnechea | - | San Luis | 3:1 | ||||
| 4. Round | 09/03/2022 | San Luis | - | Santiago Wanderers | 1:1 |  |
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| 5. Round | 16/03/2022 | San Luis | - | Santiago Morning | 1:2 | ||||
| 6. Round | 23/03/2022 | Rangers | - | San Luis | 2:3 | |
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| 7. Round | 03/04/2022 | San Luis | - | Deportes Copiapó | 0:0 | |
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| 8. Round | 12/04/2022 | Unión San Felipe | - | San Luis | 2:0 | ||||
| 9. Round | 18/04/2022 | San Luis | - | Deportes Melipilla | 2:1 | |
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| 10. Round | 21/04/2022 | Puerto Montt | - | San Luis | 1:1 | ||||
| 14. Round | 13/05/2022 | San Luis | - | Fernández Vial | 0:0 | ||||
| 15. Round | 18/05/2022 | Santa Cruz | - | San Luis | 2:0 | ||||
| 16. Round | 23/05/2022 | Recoleta | - | San Luis | 2:3 | ||||
| 17. Round | 01/06/2022 | San Luis | - | Universidad de Concepción | 0:2 |
Chile