| 4. Round | 26/01/2002 | Santos Laguna | - | Cruz Azul | 2:2 | ||||
| 5. Round | 02/02/2002 | Pumas UNAM | - | Santos Laguna | 3:4 | ||||
| 6. Round | 09/02/2002 | Santos Laguna | - | Club León | 3:0 | ||||
| 7. Round | 16/02/2002 | Club Necaxa | - | Santos Laguna | 4:1 | ||||
| 8. Round | 23/02/2002 | Santos Laguna | - | Deportivo Toluca | 0:1 | ||||
| 9. Round | 26/02/2002 | CF Monterrey | - | Santos Laguna | 2:3 | ||||
| 12. Round | 16/03/2002 | Santos Laguna | - | UAG Tecos | 3:2 | ||||
| 13. Round | 23/03/2002 | Santos Laguna | - | Puebla FC | 3:0 | ||||
| 16. Round | 02/04/2002 | CF América | - | Santos Laguna | 2:2 |  |
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| 18. Round | 19/04/2002 | UANL Tigres | - | Santos Laguna | 2:1 | ||||
| 19. Round | 26/04/2002 | Santos Laguna | - | Veracruz (old) | 5:1 |
Mexico