| 3. Round | 29/08/2004 | Santos Laguna | - | CF América | 1:1 | ||||
| 7. Round | 25/09/2004 | CF Monterrey | - | Santos Laguna | 1:0 | ||||
| 8. Round | 29/09/2004 | Santos Laguna | - | Club Necaxa | 1:1 |  |
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| 9. Round | 02/10/2004 | Monarcas Morelia | - | Santos Laguna | 1:1 | |
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| 11. Round | 22/10/2004 | Pumas UNAM | - | Santos Laguna | 2:1 | |
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| 12. Round | 24/10/2004 | Santos Laguna | - | Atlante | 2:1 | ||||
| 13. Round | 31/10/2004 | CF Pachuca | - | Santos Laguna | 2:1 | ||||
| 14. Round | 03/11/2004 | Santos Laguna | - | Deportivo Toluca | 0:1 | |
Mexico