| 7. Round | 23/10/2021 | PEC Zwolle [Youth B] | - | AFC Ajax [Youth B] | 0:2 | ||||
| 8. Round | 30/10/2021 | AFC Ajax [Youth B] | - | Feyenoord [Youth B] | 5:2 |  |
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| 10. Round | 20/11/2021 | AFC Ajax [Youth B] | - | FC Utrecht [Youth B] | 2:4 | |
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| 13. Round | 05/02/2022 | sc Heerenveen [Youth B] | - | AFC Ajax [Youth B] | 1:1 | ||||
| 14. Round | 16/02/2022 | AFC Ajax [Youth B] | - | PEC Zwolle [Youth B] | 4:1 | ||||
| 11. Round | 19/02/2022 | AFC Ajax [Youth B] | - | NEC Nijmegen [Youth B] | 4:0 |
Netherlands