| 1. Round | 03/07/2022 | Atlético San Luis [U20] | - | Club León [U20] | 1:3 | ||||
| 2. Round | 09/07/2022 | Deportivo Guadalajara [U20] | - | Atlético San Luis [U20] | 3:1 | ||||
| 3. Round | 17/07/2022 | Atlético San Luis [U20] | - | CF Monterrey [U20] | 2:1 |  |
|||
| 4. Round | 22/07/2022 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 5:0 | ||||
| 5. Round | 26/07/2022 | Atlético San Luis [U20] | - | Cruz Azul [U20] | 0:2 | ||||
| 6. Round | 30/07/2022 | Puebla FC [U20] | - | Atlético San Luis [U20] | 2:3 | |
|||
| 7. Round | 07/08/2022 | Atlético San Luis [U20] | - | Club Necaxa [U20] | 2:2 | ||||
| 8. Round | 11/08/2022 | Gallos Blancos [U20] | - | Atlético San Luis [U20] | 0:3 | ||||
| 9. Round | 18/08/2022 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 0:2 | ||||
| 11. Round | 28/08/2022 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 7:2 | ||||
| 12. Round | 01/09/2022 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 3:2 | ||||
| 13. Round | 06/09/2022 | CF América [U20] | - | Atlético San Luis [U20] | 5:0 | ||||
| 16. Round | 23/09/2022 | FC Juárez [U20] | - | Atlético San Luis [U20] | 3:0 |
Mexico