| 1. Round | 05/02/2022 | Blooming | - | Bolívar | 0:7 | ||||
| 2. Round | 13/02/2022 | Bolívar | - | Universitario de Vinto | 2:0 | ||||
| 3. Round | 20/02/2022 | Independiente Petrolero | - | Bolívar | 1:0 | ||||
| 4. Round | 27/02/2022 | Bolívar | - | Always Ready | 3:0 |  |
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| 5. Round | 05/03/2022 | Real Tomayapo | - | Bolívar | 1:1 |  |
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| 6. Round | 14/03/2022 | The Strongest | - | Bolívar | 0:1 | ||||
| 7. Round | 03/04/2022 | Bolívar | - | Royal Pari | 6:0 | |
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| 8. Round | 09/04/2022 | Bolívar | - | Jorge Wilstermann | 0:1 | |
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| 9. Round | 16/04/2022 | Bolívar | - | Blooming | 6:0 | ||||
| 10. Round | 19/04/2022 | Universitario de Vinto | - | Bolívar | 1:4 | ||||
| 11. Round | 23/04/2022 | Bolívar | - | Independiente Petrolero | 3:1 | |
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| 12. Round | 01/05/2022 | Always Ready | - | Bolívar | 1:2 | ||||
| 13. Round | 08/05/2022 | Bolívar | - | The Strongest | 1:0 | ||||
| 14. Round | 13/05/2022 | Bolívar | - | Real Tomayapo | 1:0 | ||||
| 15. Round | 15/05/2022 | Royal Pari | - | Bolívar | 2:1 |  |
Bolivia