1. Round | 08/01/2022 | Deportivo Guadalajara [] | - | Atlético San Luis [] | 2:0 | ||||
2. Round | 16/01/2022 | Atlético San Luis [] | - | Mazatlán FC [] | 2:1 | ||||
3. Round | 22/01/2022 | Club Tijuana [] | - | Atlético San Luis [] | 5:0 | ||||
4. Round | 29/01/2022 | Atlético San Luis [] | - | Atlas Guadalajara [] | 0:2 | ||||
5. Round | 04/02/2022 | Atlético San Luis [] | - | Santos Laguna [] | 0:2 | ||||
6. Round | 12/02/2022 | Club León [] | - | Atlético San Luis [] | 1:0 | ||||
8. Round | 26/02/2022 | CF Monterrey [] | - | Atlético San Luis [] | 7:0 | ||||
9. Round | 05/03/2022 | Atlético San Luis [] | - | UANL Tigres [] | 0:2 | ||||
10. Round | 12/03/2022 | Atlético San Luis [] | - | Deportivo Guadalajara [] | 0:2 | ||||
11. Round | 19/03/2022 | Santos Laguna [] | - | Atlético San Luis [] | 2:2 | ||||
12. Round | 26/03/2022 | Atlético San Luis [] | - | CF Monterrey [] | 0:3 | ||||
13. Round | 02/04/2022 | UANL Tigres [] | - | Atlético San Luis [] | 2:0 | ||||
15. Round | 03/05/2022 | Atlético San Luis [] | - | Club León [] | 0:3 |