| 2. Round | 20/08/2021 | Brighton & Hove Albion U23 | - | West Ham United U23 | 4:2 | ||||
| 3. Round | 28/08/2021 | Liverpool FC U23 | - | Brighton & Hove Albion U23 | 1:1 | ||||
| 4. Round | 10/09/2021 | Brighton & Hove Albion U23 | - | Blackburn Rovers U23 | 4:1 | ||||
| 8. Round | 16/10/2021 | Brighton & Hove Albion U23 | - | Crystal Palace U23 | 2:1 | ||||
| 9. Round | 22/10/2021 | Leeds United U23 | - | Brighton & Hove Albion U23 | 1:1 |  |
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| 13. Round | 26/11/2021 | Chelsea FC U23 | - | Brighton & Hove Albion U23 | 1:1 | ||||
| 14. Round | 03/12/2021 | Brighton & Hove Albion U23 | - | Liverpool FC U23 | 3:0 | ||||
| 16. Round | 07/01/2022 | Brighton & Hove Albion U23 | - | Arsenal FC U23 | 1:1 |
Ireland