| 1. Round | 30/04/2022 | Miramar Misiones | - | Progreso | 0:1 | ||||
| 2. Round | 07/05/2022 | Progreso | - | Villa Española | 2:0 | ||||
| 4. Round | 22/05/2022 | Progreso | - | Racing | 0:2 | ||||
| 7. Round | 05/06/2022 | Progreso | - | La Luz | 2:4 | ||||
| 8. Round | 10/06/2022 | Atenas | - | Progreso | 1:0 | ||||
| 9. Round | 18/06/2022 | Progreso | - | CA Cerro | 0:0 | ||||
| 10. Round | 22/06/2022 | Sud América | - | Progreso | 1:1 | ||||
| 11. Round | 25/06/2022 | Progreso | - | Central Español | 1:1 | ||||
| 12. Round | 23/07/2022 | Progreso | - | Miramar Misiones | 1:1 | ||||
| 13. Round | 30/07/2022 | Villa Española | - | Progreso | 0:0 | ||||
| 14. Round | 06/08/2022 | Progreso | - | Juventud de Las Piedras | 0:1 | ||||
| 15. Round | 14/08/2022 | Racing | - | Progreso | 2:1 | ||||
| 16. Round | 20/08/2022 | Progreso | - | Rampla Juniors | 0:1 | ||||
| 17. Round | 24/08/2022 | Uruguay Montevideo | - | Progreso | 1:0 | ||||
| 18. Round | 28/08/2022 | La Luz | - | Progreso | 1:1 | ||||
| 19. Round | 03/09/2022 | Progreso | - | Atenas | 1:0 | ||||
| 20. Round | 10/09/2022 | CA Cerro | - | Progreso | 1:1 |  |
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| 21. Round | 17/09/2022 | Progreso | - | Sud América | 3:1 | |
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| 22. Round | 25/09/2022 | Central Español | - | Progreso | 1:1 |
Uruguay