| 1. Round | 06/02/2016 | Fénix | - | River Plate | 1:1 | ||||
| 2. Round | 13/02/2016 | River Plate | - | Nacional | 0:3 | ||||
| 5. Round | 06/03/2016 | Racing | - | River Plate | 0:1 | ||||
| 6. Round | 20/03/2016 | River Plate | - | Plaza Colonia | 0:1 | ||||
| 11. Round | 08/05/2016 | Rentistas | - | River Plate | 2:1 | ||||
| 12. Round | 14/05/2016 | River Plate | - | El Tanque Sisley | 1:0 | ||||
| 13. Round | 22/05/2016 | Liverpool | - | River Plate | 1:0 | ||||
| 14. Round | 29/05/2016 | River Plate | - | Defensor Sporting | 1:2 | ||||
| 15. Round | 05/06/2016 | Villa Teresa | - | River Plate | 2:0 |
Uruguay