| 1. Round | 01/02/2025 | Defensor Sporting | - | Boston River | 2:0 | ||||
| 2. Round | 09/02/2025 | Boston River | - | Montevideo City Torque | 0:0 |  |
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| 5. Round | 09/03/2025 | Progreso | - | Boston River | 2:2 | ||||
| 7. Round | 22/03/2025 | Boston River | - | Racing | 1:3 | ||||
| 10. Round | 05/04/2025 | Juventud de Las Piedras | - | Boston River | 4:1 | ||||
| 15. Round | 20/05/2025 | Boston River | - | CA Cerro | 0:0 |
Uruguay