| 21. Round | 05/02/2022 | Arminia Bielefeld | - | Bor. Mönchengladbach | 1:1 | ||||
| 22. Round | 13/02/2022 | 1899 Hoffenheim | - | Arminia Bielefeld | 2:0 | ||||
| 24. Round | 26/02/2022 | Bayer Leverkusen | - | Arminia Bielefeld | 3:0 | ||||
| 25. Round | 04/03/2022 | Arminia Bielefeld | - | FC Augsburg | 0:1 | ||||
| 26. Round | 13/03/2022 | Borussia Dortmund | - | Arminia Bielefeld | 1:0 | ||||
| 27. Round | 19/03/2022 | 1. FSV Mainz 05 | - | Arminia Bielefeld | 4:0 | ||||
| 30. Round | 17/04/2022 | Arminia Bielefeld | - | Bayern München | 0:3 | ||||
| 31. Round | 23/04/2022 | 1. FC Köln | - | Arminia Bielefeld | 3:1 | ||||
| 32. Round | 30/04/2022 | Arminia Bielefeld | - | Hertha BSC | 1:1 | ||||
| 33. Round | 06/05/2022 | VfL Bochum | - | Arminia Bielefeld | 2:1 |
Nigeria