| 4. Round | 09/07/2021 | Nashville SC | - | Atlanta United FC | 2:2 | ||||
| 4. Round | 17/07/2021 | Atlanta United FC | - | New England Revolution | 0:1 | ||||
| 4. Round | 31/07/2021 | Orlando City | - | Atlanta United FC | 3:2 | ||||
| 5. Round | 05/08/2021 | CF Montréal | - | Atlanta United FC | 2:2 |  |
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| 5. Round | 08/08/2021 | Columbus Crew | - | Atlanta United FC | 2:3 | ||||
| 5. Round | 19/08/2021 | Atlanta United FC | - | Toronto FC | 1:0 | ||||
| 5. Round | 22/08/2021 | D.C. United | - | Atlanta United FC | 1:2 | ||||
| 6. Round | 11/09/2021 | Atlanta United FC | - | Orlando City | 3:0 |  |
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| 6. Round | 16/09/2021 | Atlanta United FC | - | FC Cincinnati | 4:0 | ||||
| 6. Round | 18/09/2021 | Atlanta United FC | - | D.C. United | 3:2 | ||||
| 6. Round | 25/09/2021 | Philadelphia Union | - | Atlanta United FC | 1:0 | ||||
| 6. Round | 30/09/2021 | Atlanta United FC | - | Inter Miami CF | 1:0 | ||||
| 7. Round | 28/10/2021 | Atlanta United FC | - | Inter Miami CF | 2:1 | ||||
| 8. Round | 03/11/2021 | New York RB | - | Atlanta United FC | 0:0 | ||||
| 8. Round | 07/11/2021 | FC Cincinnati | - | Atlanta United FC | 1:2 |
USA