1. Round | 25/04/2021 | Louisville City FC | - | Atlanta United II | 2:0 | ||||
2. Round | 30/05/2021 | Louisville City FC | - | Indy Eleven | 1:2 | ||||
4. Round | 03/07/2021 | Sporting Kansas City 2 | - | Louisville City FC | 2:4 | ||||
4. Round | 15/07/2021 | Louisville City FC | - | OKC Energy FC | 3:1 | ||||
4. Round | 18/07/2021 | Louisville City FC | - | Atlanta United II | 2:0 | ||||
4. Round | 01/08/2021 | Louisville City FC | - | OKC Energy FC | 2:1 | ||||
6. Round | 04/09/2021 | Louisville City FC | - | FC Tulsa | 0:1 | ||||
6. Round | 12/09/2021 | OKC Energy FC | - | Louisville City FC | 1:1 | ||||
6. Round | 30/09/2021 | Atlanta United II | - | Louisville City FC | 1:1 |