| 12. Round | 02/01/2001 | AEK Athen | - | Paniliakos Pyrgos | 2:1 | ||||
| 13. Round | 06/01/2001 | Paniliakos Pyrgos | - | Panachaiki GE | 2:2 | ||||
| 14. Round | 13/01/2001 | PS Kalamata | - | Paniliakos Pyrgos | 1:1 | ||||
| 15. Round | 20/01/2001 | Paniliakos Pyrgos | - | PAS Giannina | 1:0 | ||||
| 16. Round | 27/01/2001 | Panionios GSS | - | Paniliakos Pyrgos | 0:1 | ||||
| 17. Round | 03/02/2001 | Paniliakos Pyrgos | - | Aris Saloniki | 1:2 |  |
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| 18. Round | 10/02/2001 | OFI Heraklion | - | Paniliakos Pyrgos | 2:2 | ||||
| 19. Round | 17/02/2001 | Olympiakos Piraeus | - | Paniliakos Pyrgos | 2:0 | ||||
| 20. Round | 23/02/2001 | Paniliakos Pyrgos | - | Panathinaikos | 0:3 | ||||
| 21. Round | 03/03/2001 | PAOK Saloniki | - | Paniliakos Pyrgos | 3:2 | ||||
| 22. Round | 10/03/2001 | Paniliakos Pyrgos | - | Skoda Xanthi | 1:0 | ||||
| 23. Round | 17/03/2001 | Iraklis Saloniki | - | Paniliakos Pyrgos | 1:0 | ||||
| 27. Round | 28/04/2001 | Paniliakos Pyrgos | - | AEK Athen | 0:3 |
Greece