| 1. Round | 07/11/2021 | AE Kifisias | - | Panathinaikos II | 2:0 | ||||
| 2. Round | 14/11/2021 | Panathinaikos II | - | AEK Athen II | 0:2 | ||||
| 3. Round | 20/11/2021 | PS Kalamata | - | Panathinaikos II | 1:2 | ||||
| 5. Round | 27/11/2021 | Panathinaikos II | - | AE Karaiskakis | 2:2 | ||||
| 7. Round | 12/12/2021 | Panathinaikos II | - | Asteras Vlachioti | 2:0 | ||||
| 8. Round | 15/12/2021 | Diagoras FC | - | Panathinaikos II | 1:2 | ||||
| 9. Round | 18/12/2021 | Panathinaikos II | - | PAE Chania | 0:2 | ||||
| 10. Round | 29/12/2021 | APS Zakynthos | - | Panathinaikos II | 0:1 | ||||
| 12. Round | 08/01/2022 | GS Kallithea | - | Panathinaikos II | 1:0 | ||||
| 22. Round | 05/03/2022 | AE Karaiskakis | - | Panathinaikos II | 1:1 | ||||
| 26. Round | 26/03/2022 | PAE Chania | - | Panathinaikos II | 2:0 | ||||
| 27. Round | 30/03/2022 | Panathinaikos II | - | APS Zakynthos | 1:1 | ||||
| 28. Round | 02/04/2022 | OFI Ierapetra | - | Panathinaikos II | 2:0 |
Greece