| 1. Round | 21/08/2021 | Harkemase Boys | - | VV GOES | 3:3 | ||||
| 2. Round | 28/08/2021 | SteDoCo | - | Harkemase Boys | 1:1 | ||||
| 3. Round | 04/09/2021 | Harkemase Boys | - | DVS'33 | 2:1 |  |
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| 4. Round | 11/09/2021 | HSV Hoek | - | Harkemase Boys | 2:2 | ||||
| 6. Round | 25/09/2021 | ACV Assen | - | Harkemase Boys | 0:1 | ||||
| 7. Round | 02/10/2021 | Harkemase Boys | - | BVV Barendrecht | 2:4 | ||||
| 8. Round | 09/10/2021 | Sportlust '46 | - | Harkemase Boys | 4:1 | ||||
| 9. Round | 16/10/2021 | Harkemase Boys | - | VV Sint Bavo | 4:2 | ||||
| 10. Round | 30/10/2021 | Ter Leede | - | Harkemase Boys | 0:1 | ||||
| 11. Round | 06/11/2021 | Harkemase Boys | - | VV Staphorst | 5:0 | ||||
| 12. Round | 13/11/2021 | Excelsior '31 | - | Harkemase Boys | 3:2 | ||||
| 14. Round | 27/11/2021 | Harkemase Boys | - | Sparta Nijkerk | 2:3 |
Netherlands