| 11. Round | 06/11/2021 | Moulins Yzeure Foot | - | Andrézieux-Bouthéon FC | 2:1 | ||||
| 12. Round | 19/11/2021 | Andrézieux-Bouthéon FC | - | AS Béziers | 2:1 |  |
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| 7. Round | 07/01/2022 | FC Nantes B | - | Andrézieux-Bouthéon FC | 1:0 | ||||
| 17. Round | 05/02/2022 | Montpellier HSC B | - | Andrézieux-Bouthéon FC | 0:2 | ||||
| 19. Round | 18/02/2022 | Bergerac Périgord FC | - | Andrézieux-Bouthéon FC | 0:0 |
Guinea