1. Round | 08/01/2018 | Santos Laguna | - | Lobos BUAP | 4:2 | ||||
2. Round | 14/01/2018 | UANL Tigres | - | Santos Laguna | 2:1 | ||||
3. Round | 22/01/2018 | Santos Laguna | - | Monarcas Morelia | 1:0 | ||||
10. Round | 04/03/2018 | Club Necaxa | - | Santos Laguna | 1:2 | ||||
11. Round | 12/03/2018 | Santos Laguna | - | CF Monterrey | 3:2 | ||||
12. Round | 17/03/2018 | Puebla FC | - | Santos Laguna | 0:1 | ||||
13. Round | 31/03/2018 | Atlas Guadalajara | - | Santos Laguna | 3:2 | ||||
14. Round | 09/04/2018 | Santos Laguna | - | Gallos Blancos | 3:0 | ||||
15. Round | 15/04/2018 | CF Pachuca | - | Santos Laguna | 3:1 | ||||
16. Round | 23/04/2018 | Santos Laguna | - | Pumas UNAM | 1:2 | ||||
17. Round | 29/04/2018 | CF América | - | Santos Laguna | 1:0 |