| 3. Round | 30/01/2022 | CD Zap | - | Cafetaleros de Chiapas | 1:4 | ||||
| 4. Round | 04/02/2022 | Inter Playa | - | CD Zap | 3:2 | ||||
| 5. Round | 12/02/2022 | Inter de Querétaro | - | CD Zap | 0:3 | ||||
| 6. Round | 20/02/2022 | CD Zap | - | Montañeses FC | 0:1 | ||||
| 7. Round | 26/02/2022 | Leviatán FC | - | CD Zap | 0:4 | ||||
| 10. Round | 18/03/2022 | CD Zap | - | Lobos ULMX | 3:1 | ||||
| 8. Round | 24/03/2022 | CD Zap | - | Sporting Canamy | 2:1 | ||||
| 11. Round | 27/03/2022 | Reboceros de La Piedad | - | CD Zap | 1:2 | ||||
| 2. Round | 30/03/2022 | Escorpiones | - | CD Zap | 1:0 | ||||
| 12. Round | 03/04/2022 | CD Zap | - | Deportivo Dongu | 2:1 | ||||
| 13. Round | 09/04/2022 | Cañoneros FC | - | CD Zap | 3:2 |
Mexico