| 8. Round | 08/11/2020 | Cafessa Jalisco | - | Cañoneros Marina | 1:0 | ||||
| 9. Round | 15/11/2020 | Cruz Azul Hidalgo | - | Cafessa Jalisco | 0:1 | ||||
| 10. Round | 22/11/2020 | Cafessa Jalisco | - | CD Cuautla | 2:2 | ||||
| 11. Round | 29/11/2020 | Deportivo Dongu | - | Cafessa Jalisco | 0:1 | ||||
| 12. Round | 06/12/2020 | Cafessa Jalisco | - | Aguacateros CDU | 4:1 |  |
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| 13. Round | 12/12/2020 | Pioneros de Cancún | - | Cafessa Jalisco | 0:3 | ||||
| 3. Round | 16/12/2020 | Zitácuaro | - | Cafessa Jalisco | 1:3 | ||||
| 14. Round | 17/01/2021 | Cafessa Jalisco | - | Inter Playa | 0:2 | ||||
| 15. Round | 23/01/2021 | Cafetaleros de Chiapas | - | Cafessa Jalisco | 0:0 | ||||
| 16. Round | 02/02/2021 | Cafessa Jalisco | - | Zitácuaro | 2:0 | ||||
| 17. Round | 07/02/2021 | Azores de Hidalgo | - | Cafessa Jalisco | 2:0 | |
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| 24. Round | 01/04/2021 | Cafessa Jalisco | - | Deportivo Dongu | 1:0 |  |
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| 25. Round | 03/04/2021 | Aguacateros CDU | - | Cafessa Jalisco | 1:0 | |
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| 26. Round | 10/04/2021 | Cafessa Jalisco | - | Pioneros de Cancún | 0:0 |
Mexico