| 2. Round | 24/09/2021 | CD Zap | - | Escorpiones | 2:1 | ||||
| 3. Round | 02/10/2021 | Cafetaleros de Chiapas | - | CD Zap | 2:1 | ||||
| 4. Round | 08/10/2021 | CD Zap | - | Inter Playa | 1:5 |  |
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| 5. Round | 13/10/2021 | CD Zap | - | Inter de Querétaro | 2:1 | ||||
| 6. Round | 17/10/2021 | Montañeses FC | - | CD Zap | 1:0 | |
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| 7. Round | 22/10/2021 | CD Zap | - | Leviatán FC | 3:0 | ||||
| 8. Round | 30/10/2021 | Sporting Canamy | - | CD Zap | 0:1 |  |
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| 9. Round | 05/11/2021 | CD Zap | - | Yalmakan FC | 1:3 | |
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| 10. Round | 11/11/2021 | Lobos ULMX | - | CD Zap | 1:2 | ||||
| 11. Round | 14/11/2021 | CD Zap | - | Reboceros de La Piedad | 0:2 | ||||
| 12. Round | 20/11/2021 | Deportivo Dongu | - | CD Zap | 0:2 | ||||
| 13. Round | 26/11/2021 | CD Zap | - | Cañoneros FC | 6:2 |
Mexico